NF-E2-related factor 2 (nuclear factor erythroid-2-related factor, Nrf2) is a redox sensitive transcription factor Nrf2 activation by oxidative response element (antioxidant response element, ARE) role, can activate many metabolic detoxifying enzymes and antioxidant proteins, and therefore, the loss of Nrf2 function in the body, will promote the progress of many cancerous carcinogens, including stomach cancer, liver cancer, skin cancer, colorectal cancer and so on. Therefore, Nrf2 play an important role in inhibiting cell carcinoma of defense and antioxidant protection, etc., Nrf2 activator traditionally considered to be a potential cancer protective substances (chemopreventive agents). Although Nrf2 activator help to prevent normal cell carcinoma, in the treatment of cancer, but we hope to have its inhibitor, as the cancer cells more than normal resilience, so that when the chemotherapeutic drugs, because cancer cells subjected to metabolic stress, while generating organelles accumulate a large number of damaged or denatured proteins, thereby inducing oxidative stress, cancer cells to quickly repair the damage caused by chemotherapy, which will generate a large number of activated Nrf2, and through the similar protection mechanisms within normal cells clear damaged organelles own cells and toxins. Therefore, its relationship with the known antioxidant Nrf2 in normal cells and cancer cells plays a role in the double-edged. Therefore, the development of novel inhibitors of Nrf2 resistance will reduce the use of anti-cancer drugs due to the more favorable treatment of cancer.
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